Korteketen

Korteketen is a Dutch term that translates literally to "short chain." In chemistry and biology it most commonly refers to short‑chain fatty acids (SCFAs), compounds with a carbon backbone of fewer than six carbon atoms. Typical examples are acetate, propionate, butyrate, and valerate. SCFAs arise naturally in the human gut through fermentation of dietary fibers by gut microbiota. They act as signaling molecules, influence host metabolism, and play a role in inflammatory regulation. In industrial applications, short‑chain alcohols derived from keten (ketones) are used as solvents, cleaners and in the synthesis of polymers. In the context of organic synthesis, a keten (short‑chain ketone) can undergo the Wolff rearrangement to yield a carbene that subsequently forms a stabilized carbenoid.

In Dutch culinary and food science literature korteketen compounds are cited for their aroma attributes in dairy products and fermented beverages. Their volatility contributes to the aroma profile of cheeses, butters, and fermented meats. Regulatory agencies, such as the European Food Safety Authority, monitor concentrations of SCFAs in food to ensure safety. The name “korteketen” is also used in logistics to denote a short supply chain that includes only a few intermediaries between producer and consumer, aiming to improve traceability and reduce waste.

Short‑chain compounds have also found application in medical research; SCFAs have been shown to influence host gene expression through histone deacetylase inhibition. In agricultural settings, SCFAs are studied for their potential to promote growth in poultry and to reduce parasite load in livestock. The term korteketen thus spans several scientific and industrial domains, all revolving around the concept of a chemical species or process involving a comparatively small carbon chain.