Hypofibrinogenaemi

Hypofibrinogenemia is a medical condition characterized by abnormally low levels of fibrinogen in the blood. Fibrinogen, also known as factor I, is a crucial protein produced by the liver that plays a vital role in blood clotting. It is converted into fibrin, which forms a mesh that traps blood cells and platelets, forming a clot to stop bleeding.

There are two main types of hypofibrinogenemia: congenital and acquired. Congenital hypofibrinogenemia is a rare inherited disorder where the body does not produce enough fibrinogen from birth. Acquired hypofibrinogenemia can develop later in life due to various factors such as liver disease, malnutrition, disseminated intravascular coagulation (DIC), or certain medications.

The symptoms of hypofibrinogenemia can range from mild to severe, depending on the degree of fibrinogen deficiency. Individuals may experience excessive bruising, nosebleeds, prolonged bleeding from cuts, and in severe cases, spontaneous internal bleeding. Women with this condition may have heavy or prolonged menstrual bleeding.

Diagnosis typically involves blood tests to measure fibrinogen levels. Other tests may be performed to identify the underlying cause. Treatment strategies depend on the cause and severity. For congenital forms, treatment may involve fibrinogen replacement therapy. For acquired forms, addressing the underlying condition is the primary focus. Maintaining adequate fibrinogen levels is essential for proper hemostasis and preventing potentially life-threatening bleeding events.