Histokeemiat
Histokeemiat is an interdisciplinary discipline that studies the chemical composition and chemical processes in biological tissues using histological and chemical imaging approaches. It integrates histochemistry, analytical chemistry, and imaging to map spatial distributions of molecules such as metabolites, minerals, and signaling molecules within tissue sections.
Etymology and scope: The term combines 'histology' and 'keemia' (chemistry) to indicate a focus on chemical phenomena
Techniques: Core methods include histochemical staining, immunohistochemistry, fluorescence imaging, mass spectrometry imaging (MSI), Raman and infrared
Applications: In pathology, histokeemiat supports characterization of metabolic states, mineral deposition, or biomarker distributions in disease.
Limitations and status: The term is not widely standardized; methods and reporting practices vary. Reproducibility, sample