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HOXA9

HOXA9 is a protein-coding gene in humans that belongs to the homeobox family of transcription factors. The gene is located on chromosome 7 and encodes a DNA-binding protein that plays crucial roles in embryonic development and cellular differentiation.

The HOXA9 protein contains a highly conserved 60-amino acid homeodomain that allows it to bind specific DNA

During embryogenesis, HOXA9 is expressed in specific regions including the developing limbs, genital tubercle, and hematopoietic

HOXA9 has clinical significance due to its involvement in certain cancers. Chromosomal translocations involving the HOXA9

Research has shown that HOXA9 interacts with other transcription factors and cofactors to form regulatory complexes

Understanding HOXA9 function has important implications for developmental biology and cancer research. The gene represents a

sequences
and
regulate
gene
expression.
As
part
of
the
HOXA
gene
cluster,
it
is
organized
in
a
sequential
manner
that
corresponds
to
its
expression
pattern
along
the
anterior-posterior
axis
during
development.
The
protein
functions
as
a
transcription
factor,
controlling
the
expression
of
target
genes
involved
in
developmental
processes.
system.
It
plays
essential
roles
in
patterning
and
specification
of
body
segments,
particularly
in
the
hindlimb
and
genital
development.
The
gene
is
also
critical
for
normal
blood
cell
formation
and
maintenance
of
hematopoietic
stem
cells.
gene
are
associated
with
acute
myeloid
leukemia
and
other
hematological
malignancies.
These
genetic
rearrangements
often
result
in
aberrant
expression
of
HOXA9,
contributing
to
leukemogenesis.
Additionally,
dysregulation
of
HOXA9
expression
has
been
observed
in
various
solid
tumors.
that
control
downstream
gene
expression.
Its
activity
is
tightly
regulated
through
various
mechanisms
including
post-translational
modifications
and
protein-protein
interactions.
key
regulatory
node
in
developmental
pathways
and
serves
as
a
potential
therapeutic
target
in
certain
malignancies
where
its
expression
is
dysregulated.