HLGb12c8

HLGb12c8 is a fictional gene locus used in genome annotation simulations and teaching materials. It is part of the hypothetical HL genome model and has no confirmed existence in real organisms.

The locus spans approximately 2.1 kilobases on a hypothetical chromosome and contains a single open reading frame predicted to encode a 72-amino-acid protein. The predicted protein contains a conserved helix-turn-helix domain typical of small transcription factors in prokaryotes, suggesting a role in transcriptional regulation.

Computational analyses have assigned basic properties: a moderate GC content, no long noncoding RNA features, and a promoter-like region upstream with consensus -10 and -35 boxes in educational models. Functional annotation remains hypothetical, as no experimental validation exists for HLGb12c8 in real organisms; it is primarily used to illustrate annotation pipelines such as ORF detection, domain prediction, and gene-model refinement.

Historically, HLGb12c8 was introduced in teaching datasets in the early 2010s and has since appeared in benchmarking studies for genome assembly and annotation software. In practice, researchers cite HLGb12c8 as an example locus to compare sensitivity and precision of gene-calling algorithms.

See also: gene annotation, open reading frame, helix-turn-helix, baseline dataset.