HER2ERBB2alueen

HER2ERBB2alueen refers to the gene also known as ERBB2, which is part of the human epidermal growth factor receptor family. This gene encodes a transmembrane protein that functions as a receptor for growth factors. These receptors play a crucial role in cell growth, differentiation, and survival. When these receptors are activated, they trigger a cascade of signaling pathways within the cell, ultimately influencing cellular behavior.

In certain types of cancer, the ERBB2 gene can become amplified, leading to an overexpression of the HER2 receptor on the surface of cancer cells. This overexpression can drive uncontrolled cell proliferation and contribute to tumor growth and invasiveness. Consequently, HER2ERBB2alueen has become a significant target in cancer therapy.

The discovery of HER2 overexpression as a driving factor in some breast cancers, and later in other cancers like gastric and ovarian cancers, revolutionized treatment approaches. Therapies designed to target the HER2 receptor, such as trastuzumab and pertuzumab, have significantly improved outcomes for patients with HER2-positive cancers. These targeted therapies work by blocking the HER2 receptor's signaling activity or by marking cancer cells for destruction by the immune system. Diagnostic tests are routinely used to determine HER2 status in tumors to guide treatment decisions.