GnFE
GnFE is a bacterial protein that participates in the regulation of metal ion homeostasis, particularly nickel and cobalt. The gnfe gene is typically located within the gnfe-gnfD operon found in many Gram‑negative species such as Pseudomonas aeruginosa and several Proteobacteria. Transcription of the operon is induced under metal‑limited conditions.
The GnFE protein is predicted to be a periplasmic protein containing an N‑terminal signal peptide that directs
Functionally, GnFE interacts with the membrane‑associated transcriptional regulator GnfD. Together they form a two‑component regulatory system
Evolutionary analyses indicate that GnFE homologs are widespread among bacteria possessing metal‑transport regulons, but are absent
Research on GnFE has implications for biotechnology, particularly in the design of bacteria capable of bio‑remediation