Genominia

Genominia is a term used in speculative discussions to describe an integrated, systems-level approach to studying genomes. In this framing, the genome is viewed not merely as a sequence of nucleotides but as a dynamic, spatially organized information architecture whose structure and regulation shape phenotypes across conditions and species. The concept emphasizes interactions among genetic variation, epigenetic states, chromatin organization, transcriptional programs, and cellular context.

Proponents envision genominia as a unifying framework that combines genomics, epigenomics, chromatin conformation capture, transcriptomics, proteomics, and computational modeling to predict how changes at the DNA level propagate through regulatory networks to produce observable traits. Methodologically, it relies on multi-omics data integration, single-cell techniques, and machine learning to build models of genome function that account for three-dimensional genome organization and dynamic regulation.

Genominia is not an established field in mainstream biology; it is largely theoretical or used in speculative writing. It overlaps with, but is not identical to, systems genomics, regulatory genomics, and integrative omics. Critics argue that the term can obscure practical distinctions between well-defined disciplines and may overstate the coherence of a single framework for genome function.

See also genomics, epigenomics, 3D genome, systems biology, regulatory genomics.