GSTZ
GSTZ, or glutathione S-transferase zeta 1, is a cytosolic enzyme in humans that is also known as maleylacetoacetate isomerase (MAAI). It belongs to the zeta class of the glutathione S-transferase (GST) family and plays a dual role in metabolism and detoxification.
In the tyrosine and phenylalanine degradation pathways, GSTZ1 catalyzes the isomerization of maleylacetoacetate to fumarylacetoacetate, a
GSTZ1 is encoded by the GSTZ1 gene, located on chromosome 14q24.3. The enzyme is expressed mainly in
Clinically, GSTZ1 polymorphisms are studied in pharmacogenomics to understand interindividual differences in drug response and in