Fluoroacetamide

Fluoroacetamide is a chemical compound with the formula CH2FCO2NH2. It is the amide of fluoroacetic acid. It is a white crystalline solid that is soluble in water. Fluoroacetamide is known for its toxicity.

Historically, fluoroacetamide has been used as a rodenticide, though its use is now restricted or banned in many countries due to its high toxicity to non-target organisms and potential for environmental contamination. It acts as a metabolic poison by interfering with the citric acid cycle, leading to a buildup of citrate in the body. This disruption of cellular respiration is lethal to mammals. Symptoms of poisoning in humans can include nausea, vomiting, abdominal pain, and neurological effects.

The synthesis of fluoroacetamide typically involves the reaction of fluoroacetic acid or its derivatives with ammonia. Due to its hazardous nature, handling and disposal of fluoroacetamide require strict safety precautions and adherence to regulatory guidelines. Research into its properties and potential applications continues, but its primary association remains with its potent pesticidal activity and associated risks.