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FOLH1

FOLH1 is a gene in humans that provides instructions for making a protein called folate hydrolase 1. This protein is primarily found in the tissues lining the digestive system, including the small intestine, and is also present in the kidneys and other parts of the body.

The function of folate hydrolase 1 is to break down folate, a B vitamin that is essential

Mutations in the FOLH1 gene can lead to disorders of folate metabolism. Individuals with these mutations may

Research has also identified FOLH1 as a potential target for cancer therapy. Folate hydrolase 1 is overexpressed

Overall, the FOLH1 gene plays a critical role in regulating folate metabolism, and mutations or disruptions

for
various
bodily
functions.
Folate
is
involved
in
the
synthesis
of
DNA
and
RNA,
the
metabolism
of
amino
acids,
and
the
transfer
of
one-carbon
units
in
biochemical
reactions.
Folate
hydrolase
1
helps
to
convert
folate
into
its
active
forms,
which
can
then
be
used
by
the
body.
be
unable
to
properly
break
down
folate,
leading
to
a
buildup
of
the
vitamin
in
the
body.
This
can
cause
symptoms
such
as
neurological
problems,
birth
defects,
and
an
increased
risk
of
certain
cancers.
in
certain
types
of
cancer,
including
ovarian
cancer.
Inhibitors
of
the
enzyme
may
be
useful
in
treating
these
types
of
cancer
by
reducing
the
amount
of
folate
available
to
the
tumor
cells.
in
its
function
can
have
significant
consequences
for
human
health.