FMNL1

FMNL1, also known as formin-like protein 1, is a protein encoded by the FMNL1 gene in humans. It belongs to the formin family of proteins, which are involved in the regulation of actin cytoskeleton dynamics. Formins are characterized by the presence of a DAD (diaphanous autoregulatory domain) and a FH2 (formin homology 2) domain, both of which are critical for their function. FMNL1 plays a role in various cellular processes that depend on actin polymerization, including cell migration, cell division, and cell adhesion.

The FMNL1 protein interacts with actin monomers and filaments, promoting the nucleation and elongation of actin cables. It can also stabilize existing actin structures. Its specific functions are often context-dependent and can be influenced by interactions with other proteins. Research suggests that FMNL1 is particularly important in the development and function of the immune system and in certain epithelial tissues. Dysregulation of FMNL1 has been implicated in some diseases, including certain types of cancer, where it may contribute to tumor growth and metastasis by affecting cell motility and invasion. Further research continues to explore the precise mechanisms and biological significance of FMNL1 in both normal physiology and disease states.