FBP1

FBP1, or Fibroblast Growth Factor Receptor 1, is a protein that functions as a receptor for fibroblast growth factors (FGFs). It is a member of the tyrosine kinase receptor family and plays a crucial role in various cellular processes, including cell proliferation, differentiation, migration, and survival. FBP1 is encoded by the FGFR1 gene, which is located on chromosome 8 in humans.

FBP1 is composed of an extracellular ligand-binding domain, a transmembrane domain, and an intracellular tyrosine kinase domain. Upon binding to its ligands, FBP1 undergoes autophosphorylation, leading to the activation of downstream signaling pathways. These pathways include the Ras-MAPK, PI3K-Akt, and PLCγ-PKC pathways, which are involved in regulating cell growth, survival, and migration.

Mutations in the FGFR1 gene have been associated with several human diseases, including craniosynostosis, achondroplasia, and thanatophoric dysplasia. These mutations can lead to constitutive activation of FBP1, resulting in abnormal cell signaling and tissue development. Additionally, FBP1 has been implicated in cancer development, as its activation can promote tumor growth and progression.

FBP1 is also a target for therapeutic intervention in various diseases. Small molecule inhibitors of FBP1 have been developed and are being studied for their potential to treat cancer and other diseases characterized by FBP1 activation. Furthermore, FBP1 has been explored as a potential target for regenerative medicine, as its activation can promote tissue repair and regeneration.