FABPpm

FABPpm, or Fatty Acid Binding Protein (FABP) plasma membrane, is a protein that plays a crucial role in the transport of fatty acids across cell membranes. It is a member of the FABP family, which includes several isoforms found in various tissues and cells. FABPpm is primarily expressed in the plasma membrane of cells, where it facilitates the movement of fatty acids into and out of the cell.

The function of FABPpm is particularly important in tissues that require a high flux of fatty acids, such as muscle and adipose tissue. It acts as a shuttle, binding to fatty acids in the extracellular space and then transporting them into the cell's cytoplasm. Once inside the cell, the fatty acids can be used for energy production, storage, or synthesis of lipids.

FABPpm is also involved in the regulation of cellular processes. It can modulate the activity of enzymes involved in fatty acid metabolism and influence the expression of genes related to lipid metabolism. Additionally, FABPpm has been implicated in various physiological and pathological processes, including inflammation, diabetes, and cancer.

The structure of FABPpm consists of a hydrophobic binding pocket that specifically interacts with fatty acids. This pocket is lined with hydrophobic amino acids that facilitate the binding and transport of fatty acids. The protein also contains a transmembrane domain that anchors it to the plasma membrane.

Research on FABPpm is ongoing, with studies focusing on its potential as a therapeutic target for various diseases. Its role in fatty acid transport and metabolism makes it a promising candidate for the development of new treatments for conditions such as obesity, diabetes, and cardiovascular diseases.