EphA9

EphA9 is a member of the Eph receptor tyrosine kinase family. These receptors are involved in cell-cell communication and play crucial roles in various developmental processes, including embryogenesis, tissue development, and wound healing. Eph receptors are activated by binding to their corresponding Ephrin ligands, which are typically membrane-bound proteins. Upon ligand binding, EphA9 undergoes autophosphorylation and initiates intracellular signaling cascades that influence cell adhesion, migration, proliferation, and differentiation.

The EphA9 gene is expressed in a variety of tissues throughout the body, with notable expression in the nervous system, cardiovascular system, and immune cells. Its precise roles are still being actively researched, but studies suggest involvement in neuronal guidance, vascular development, and the regulation of immune responses. Dysregulation of EphA9 signaling has been implicated in certain diseases, including cancer, where it can affect tumor growth and metastasis, and neurological disorders. Research into EphA9's functions continues to uncover its complex involvement in both normal physiological processes and disease pathogenesis.