EGPA
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg–Strauss syndrome, is a rare form of systemic vasculitis that primarily affects small- to medium-sized vessels. It is classified among the ANCA-associated vasculitides and is characterized by eosinophil-rich granulomatous inflammation and necrotizing vasculitis. The illness often progresses through phases, commonly starting with allergic manifestations, followed by marked eosinophilia and tissue infiltration, and then systemic vasculitis.
Most patients present with a history of asthma and notable eosinophilia, along with allergic rhinitis or sinusitis.
Diagnosis relies on a combination of clinical presentation, laboratory findings, imaging, and histology. The classic approach
Treatment centers on suppressing the inflammatory response. Induction therapy typically starts with corticosteroids; organ-threatening disease or
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