EGFRERBBperhe
The EGFR/ERBB family, also known as the ERBB receptors or HER receptors, is a subfamily of receptor tyrosine kinases that regulate cellular growth, differentiation and survival. In humans, four members are enzymatic receptors: EGFR (ERBB1/HER1), ERBB2 (HER2), ERBB3 (HER3) and ERBB4 (HER4).
Activation occurs when ligands bind to the extracellular domain, promoting receptor dimerization (homo- or heterodimers) and
Downstream signaling engages pathways such as RAS-RAF-MEK-ERK and PI3K-AKT, with additional inputs from JAK/STAT and PKC,
Dysregulation is common in cancer. ERBB2 amplification occurs in a substantial subset of breast cancers and