ERBB3ERBB4

ERBB3ERBB4, also known as HER3HER4, is a protein complex formed by the interaction of two receptor tyrosine kinases, ERBB3 and ERBB4. These receptors are members of the epidermal growth factor receptor (EGFR) family, which plays a crucial role in cell signaling and regulation of various cellular processes, including proliferation, differentiation, and survival.

ERBB3 and ERBB4 are structurally similar to other EGFR family members, such as HER1 (EGFR) and HER2 (ERBB2), and share similar ligand-binding domains. However, they lack intrinsic tyrosine kinase activity and require dimerization with other EGFR family members to become activated. ERBB3ERBB4 complexes are typically formed with HER1 or HER2, and this interaction is essential for their biological function.

The ERBB3ERBB4 complex has been implicated in various biological processes, including cell migration, invasion, and angiogenesis. It is also involved in the development and progression of several types of cancer, including breast, lung, and colorectal cancer. Targeting the ERBB3ERBB4 complex has emerged as a promising therapeutic strategy for cancer treatment, with several small molecule inhibitors and monoclonal antibodies currently in clinical development.

In summary, ERBB3ERBB4 is a protein complex formed by the interaction of ERBB3 and ERBB4, which plays a crucial role in cell signaling and regulation of various cellular processes. Its involvement in cancer development and progression has made it a target for therapeutic intervention.