HER3HER4

HER3HER4 is a protein complex that plays a significant role in cell signaling and proliferation, particularly in breast cancer. The complex is composed of two members of the human epidermal growth factor receptor (HER) family: HER3 and HER4. HER3 and HER4 are both tyrosine kinase receptors that, when activated, can initiate downstream signaling pathways that promote cell growth, survival, and proliferation.

The HER3HER4 complex is formed when HER3 and HER4 heterodimerize, leading to the activation of their tyrosine kinase domains. This activation can result in the phosphorylation of various substrates, including other HER receptors, adaptor proteins, and signaling molecules. The signaling pathways activated by the HER3HER4 complex include the PI3K/Akt/mTOR, Ras/Raf/MEK/ERK, and JAK/STAT pathways, which are all involved in promoting cell proliferation and survival.

The HER3HER4 complex has been shown to be overexpressed in various types of cancer, including breast, lung, and colorectal cancer. In breast cancer, the HER3HER4 complex has been implicated in promoting tumor growth, metastasis, and resistance to therapy. Targeting the HER3HER4 complex has emerged as a promising strategy for cancer treatment, with several small-molecule inhibitors currently in clinical development.

In summary, HER3HER4 is a protein complex composed of HER3 and HER4 that plays a crucial role in cell signaling and proliferation. Its activation can lead to the promotion of tumor growth and metastasis, making it a potential target for cancer therapy. Further research is needed to fully understand the role of the HER3HER4 complex in cancer and to develop effective therapies targeting this complex.