Depyrogenointi
Depyrogenointi is a term used in the pharmaceutical and biotechnology industries to describe the process of removing pyrogens from materials. Pyrogens are fever-inducing substances, typically bacterial endotoxins, that can cause serious adverse reactions if administered to patients. These endotoxins are components of the cell walls of Gram-negative bacteria.
The primary goal of depyrogenation is to ensure the safety of injectable drug products, medical devices, and
Several methods are employed for depyrogenation. Heat sterilization, particularly dry heat sterilization at high temperatures (e.g.,
Chemical methods, such as the use of detergents or strong oxidizing agents, can also be used, but