Dendriitins

Dendriitins are a proposed class of macromolecules that exhibit a highly branched, tree-like topology akin to dendrimers. The term appears in various theoretical or speculative contexts to describe synthetic or natural polymers that accumulate branching in discrete generations. There is no universally accepted definition, and usage of the term varies among sources.

Structurally, dendriitins feature a central core, successive branching generations, and a peripheral layer of functional groups. This architecture yields a well-defined molecular size and a high surface area relative to mass. Generations are often denoted G0, G1, G2, and so on, with the number of terminal groups increasing with each generation according to the branching unit employed.

Synthesis of dendriitins typically proceeds by iterative, convergent or divergent approaches, assembling monomers with orthogonal reactive sites to build a tree-like structure. Challenges include achieving narrow polydispersity, precise generation control, and purification of intermediates. Variants may use protective group strategies or click chemistries to assemble branches in a controlled fashion.

Properties of dendriitins depend on the chosen monomer units and core. They can offer high functionality, defined sizes, and tunable solubility, which makes them of interest for potential applications in drug delivery, catalysis, or sensing. In practice, dendriitins are often discussed in relation to dendrimers and hyperbranched polymers, with dendriitins representing a conceptual framework or alternative framing rather than a widely established class.

See also: dendrimer, hyperbranched polymer, dendron. The term is not widely established in standard chemical nomenclature and is largely found in speculative or theoretical discussions.