DHEAS

DHEAS, or dehydroepiandrosterone sulfate, is the sulfated form of the endogenous steroid hormone DHEA. It is produced mainly by the adrenal cortex, with smaller amounts arising from the gonads and, to a lesser extent, the brain. DHEAS serves as a circulating precursor that can be desulfated in tissues to form DHEA, which can then be converted into androgens and estrogens.

As a circulating reservoir, DHEAS is more water-soluble and has a longer half-life than DHEA, allowing it to maintain relatively stable precursor levels in the bloodstream. Its production is driven in part by adrenocorticotropic hormone (ACTH) and fluctuates with age and sex. Levels typically rise during puberty, peak in early adulthood, and then decline progressively with age. Most circulating DHEAS is bound to proteins, with only a small fraction remaining free and biologically active.

Clinically, DHEAS is measured to assess adrenal function and to help evaluate conditions affecting androgen and estrogen balance. Abnormally high levels can be associated with adrenal hyperplasia or adrenal tumors and are sometimes seen in polycystic ovary syndrome (PCOS); low levels may occur in Addison's disease or other forms of adrenal or pituitary insufficiency. DHEAS is usually interpreted as part of a broader diagnostic workup rather than as a standalone determinant.

DHEA/DHEAS supplements are marketed for various uses, including anti-aging, but evidence for clinically meaningful benefits is limited, and there is potential for hormonal side effects and interactions. Use should be discussed with a healthcare professional, especially for individuals with hormone-sensitive conditions or those taking other medications.