Colestid

Colestid is the brand name for colestipol hydrochloride, a bile acid sequestrant used to lower low-density lipoprotein (LDL) cholesterol in adults and, in some cases, children with primary hyperlipidemia or mixed dyslipidemia. It may be prescribed as part of a cholesterol-lowering regimen that includes diet and, when appropriate, other lipid-lowering medications.

Mechanism of action

Colestipol is a non-absorbable resin that binds bile acids in the intestine. This increases the excretion of bile acids in the feces, prompting the liver to convert more cholesterol into bile acids. The result is a reduction in hepatic cholesterol and upregulation of LDL receptors, leading to lower circulating LDL cholesterol.

Administration and dosing

Colestipol is available as chewable tablets and as a powder for oral suspension. It is taken by mouth with meals. Dosing is individualized and typically starts with a low amount, such as 5 g once or twice daily, with gradual increases as tolerated. The daily dose is generally titrated to achieve the desired lipid response, with a practical maximum dose expressed in divided portions throughout the day. Patients should follow a clinician’s instructions and periodic lipid monitoring. The medication can be used alone or in combination with other lipid-lowering therapies.

Side effects and interactions

Common side effects include gastrointestinal symptoms such as constipation, bloating, and flatulence. Colestipol can interfere with the absorption of fat-soluble vitamins (A, D, E, K) and other medications; to minimize interactions, other drugs should be taken at least 1 hour before or 4–6 hours after Colestid. It may also cause or worsen elevated triglyceride levels in some patients. Use under medical supervision, especially in those with liver or biliary disorders.

See also

Related bile acid sequestrants include cholestyramine and colesevelam.