Claudin1619

Claudin1619 is a putative member of the claudin family, a group of tight junction proteins that regulate paracellular permeability. The designation reflects its identification in vertebrate genomic data and its predicted molecular features as a tetraspan membrane protein typical of claudins. Like other claudins, Claudin1619 is expected to have four transmembrane segments, two extracellular loops involved in adhesion, and cytoplasmic N- and C- termini that can interact with tight junction scaffolding proteins.

Functional data for Claudin1619 are currently limited. Transcript and protein expression have not been comprehensively mapped, and there is no well-established tissue distribution. Comparative analyses indicate conservation of the claudin motif, but the exact permeability profile and physiological role of Claudin1619 remain uncharacterized. No in vivo models or loss-of-function studies have been reported, so its contribution to barrier function is hypothetical.

Clinical relevance is not established; no disease associations have been confirmed, and Claudin1619 is not part of standard clinical panels. At present, Claudin1619 is considered a provisional member of the claudin family awaiting detailed functional and structural studies. Future work including localization, interaction partners, and knockout analyses will be needed to determine its role in epithelial or endothelial barriers and any potential relevance to disease.