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CSNK1E

CSNK1E encodes casein kinase I epsilon (CKIε), a serine/threonine protein kinase in the casein kinase I family. Like other CKI family members, CKIε is constitutively active and participates in phosphorylation of diverse substrates, thereby regulating multiple cellular processes.

In circadian biology, CKIε phosphorylates core clock components, notably the PER and CRY proteins, influencing their

In signaling networks, CKIε participates in the Wnt pathway by phosphorylating Dishevelled and modulating beta-catenin activity,

The enzyme is broadly expressed and localizes predominantly in the cytoplasm with some nuclear distribution; it

Genetic variation and dysregulation of CSNK1E have been explored in relation to circadian rhythm disorders and

stability,
subcellular
localization,
and
the
timing
of
the
circadian
cycle.
Through
these
actions,
CKIε
contributes
to
the
maintenance
of
circadian
rhythms
and
responsiveness
to
environmental
cues.
which
affects
cell
proliferation
and
differentiation.
can
function
in
other
compartments
depending
on
cellular
context.
cancer
in
humans,
and
CKIε
inhibitors
and
modulators
are
used
in
research
to
study
clock
and
signaling
pathways.