CPICn

CPICn is a variant of the Cytochrome P450 (CYP) 2D6 enzyme, which is a member of the cytochrome P450 superfamily of enzymes. This enzyme is primarily responsible for the metabolism of a wide range of drugs and xenobiotics in the human body. The "n" in CPICn refers to the normal function of the enzyme, as opposed to other variants such as CPIC1, which is associated with poor metabolizer status, and CPIC2, which is associated with ultrarapid metabolizer status.

The CPICn variant is characterized by the presence of a specific amino acid sequence at positions 41 and 116, which are tyrosine and threonine, respectively. This sequence is associated with normal metabolic activity of the enzyme. Individuals with the CPICn variant typically exhibit intermediate metabolic activity, meaning they are neither ultrarapid nor poor metabolizers.

The CPICn variant is one of the most common variants of CYP2D6, with an allele frequency of approximately 40% in the general population. This variant is often used as a reference for comparing the metabolic activity of other CYP2D6 variants. It is important to note that the metabolic activity of CYP2D6 can be influenced by a variety of factors, including genetic variations, environmental factors, and age.

In the context of pharmacogenetics, understanding the CPICn variant is crucial for predicting an individual's response to drugs that are metabolized by CYP2D6. This knowledge can help healthcare providers tailor drug therapy to optimize patient outcomes and minimize adverse effects.