CLDN1CLDN24

CLDN1CLDN24 is a non-standard reference to a potential gene fusion between CLDN1 and CLDN24, two members of the claudin family of tight junction proteins. In current public annotations, there is no officially recognized gene symbol CLDN1CLDN24, and no validated CLDN1-CLDN24 fusion transcript has been widely reported. As such, CLDN1CLDN24 is not described as a canonical gene in major genomic databases.

Claudins are four-pass transmembrane proteins that contribute to the assembly and function of tight junctions, regulating paracellular permeability and maintaining epithelial and endothelial cell polarity. Claudin-1 and claudin-24 each have distinct tissue distributions and may participate in different barrier properties, with extracellular loops mediating interactions between adjacent cells and cytoplasmic tails engaging scaffolding proteins.

If a CLDN1-CLDN24 fusion existed, its product could theoretically be a chimeric claudin with altered membrane topology, localization, or interaction with tight junction components. The functional consequences would depend on the fusion breakpoint, expressed isoforms, and regulatory context, and could range from minor changes in barrier properties to broader disruption of tight junction assembly. However, such outcomes remain speculative without experimental validation.

Clinical significance for a hypothetical CLDN1CLDN24 fusion is unknown. Any proposed disease associations or diagnostic implications would require substantiation through peer-reviewed studies and official database annotation. Research on claudins continues to illuminate their roles in tissue integrity and pathology, but CLDN1CLDN24 remains, at present, a theoretical construct rather than a defined genetic entity.