CDR2like
CDR2like refers to a family of proteins sharing sequence similarity with cerebellar degeneration-related protein 2 (CDR2). In humans, the best characterized member is CDR2L, a protein encoded by the CDR2L gene. CDR2like proteins are expressed in multiple tissues, with notable presence in the cerebellum and in various tumor types. They are found in both the nucleus and the cytoplasm and are thought to participate in regulatory networks that influence transcription and signaling, though their precise cellular roles remain to be fully defined.
CDR2 and CDR2L have been studied in parallel within the context of paraneoplastic neurological syndromes. Anti-Yo
Clinically, CDR2like proteins are considered relevant to tumor-immune interactions and may serve as biomarkers for certain