CDK46n

CDK46n is a provisional designation that appears in some genomic annotation tracks as a candidate member of the cyclin-dependent kinase (CDK) family. It is not associated with a clearly defined, functionally characterized protein in peer‑reviewed literature, and its status remains uncertain in the scientific community.

As of now, there is no widely accepted curated entry for CDK46n in major public databases. The genomic context and transcript structure described for this symbol vary across datasets, and the symbol may not correspond to a confirmed gene model in a given annotation release. This uncertainty often stems from predictions, artifacts, or aliasing in different annotation pipelines rather than from validated experimental evidence.

Functionally, there is no experimental validation of a role for CDK46n. If the transcript represents a coding sequence, it would be expected to encode a serine/threonine kinase related to other CDKs and potentially be regulated by cyclins, but no conserved motifs, activity assays, or cellular functions have been demonstrated. The lack of substantiated data also means there is little information about expression patterns, subcellular localization, or involvement in cell cycle regulation.

The conservation status of CDK46n across species is unclear, and there is limited information on its evolution or biological relevance. Its designation may reflect a predicted gene, a sequencing artifact, or an annotation alias for a different CDK member in some datasets. Researchers should consult authoritative resources and verify nomenclature before drawing conclusions, and await further validation from experimental studies.

See also: Cyclin-dependent kinases, CDK4, CDK6.