CCK39
CCK-39 is a peptide hormone belonging to the cholecystokinin (CCK) family. It is one of several endogenous forms generated from the larger precursor protein pro-cholecystokinin (pro-CCK) through tissue-specific proteolytic processing. CCK-39 is produced in both the gastrointestinal tract and the brain, with its exact abundance varying by species and physiological state. Like other CCK peptides, it features a conserved C-terminal region that ends with an amidated phenylalanine, a structural feature important for receptor interaction, and its activity is modulated by tyrosine sulfation.
Biochemistry and receptors: The CCK-39 peptide shares the characteristic motifs common to CCK fragments and acts
Biosynthesis and distribution: Pro-CCK is expressed in enteroendocrine I cells of the small intestine and in
Physiological roles: In the gut, CCK-39 stimulates pancreatic enzyme secretion, promotes gallbladder contraction, relaxes the sphincter
Research and context: CCK-39 is primarily studied in research settings using immunoassays or mass spectrometry to