Bolusinjectie

Bolusinjectie refers to the intravenous administration of a single, relatively large dose of a drug or contrast agent intended to produce a rapid onset of effect. The approach is used in diverse medical contexts, including diagnostic radiology to achieve a sharp rise in plasma concentration of contrast material, emergency medicine for rapid drug effect, anesthesia induction, and certain oncological or cardiovascular procedures where a quick therapeutic response is required.

In practice, a bolus injection is performed by trained healthcare professionals using sterile technique. The drug or contrast agent is drawn into a syringe and injected quickly through an IV catheter or needle, often followed by a saline flush to ensure complete delivery and patency of the IV line. In imaging, a power injector may be used to deliver precise volumes at controlled rates to optimize the quality of the study. The specific dose, rate, and choice of agent depend on the indication, patient factors, and drug properties.

Risks associated with bolus injections include allergic or anaphylactic reactions, extravasation or tissue injury, phlebitis, and rapid hemodynamic changes that can affect heart rate or blood pressure. Some drugs require careful monitoring or avoidance in patients with certain conditions or prior adverse reactions. Bolus injection is contrasted with slower infusion therapies, which provide a prolonged, lower-concentration exposure.

Overall, bolusinjectie is a fast-acting, high-concentration administration method used when rapid clinical effect is essential, performed under strict medical supervision with appropriate monitoring.