BRPF13

BRPF13 is not a recognized human gene in major biological databases. As of current references, there is no established protein or locus with the symbol BRPF13. The BRPF nomenclature is typically associated with a small family of genes that includes BRPF1, BRPF2, and BRPF3, which encode bromodomain and PHD finger-containing proteins that function as scaffolding subunits for histone acetyltransferase (HAT) complexes of the MYST family.

Domain architecture among BRPF1–3 generally includes a bromodomain, one or more PHD (plant homeodomain) fingers, and regions that support protein–protein interactions. This arrangement enables BRPF proteins to recognize specific histone marks and to recruit catalytic HAT subunits to chromatin, thereby facilitating histone acetylation and transcriptional activation.

Functional role and interactions: BRPF1, BRPF2, and BRPF3 form part of MYOZ/MORF-type HAT complexes, associating with catalytic subunits such as MOZ (KAT6A) and MORF (KAT6B). Through these interactions, BRPF proteins help regulate chromatin structure and gene expression, influencing developmental processes and cell fate decisions. They are considered chromatin regulators with broad roles in transcriptional control.

Biological and clinical significance: In vivo studies indicate essential roles for BRPF proteins in development. Human BRPF1 mutations and haploinsufficiency have been linked to neurodevelopmental disorders. BRPF genes are active areas of epigenetic research due to their potential involvement in cancer and other diseases through dysregulated histone acetylation.

Notes: If you meant BRPF1, BRPF2, or BRPF3, see those entries for detailed information. If BRPF13 appears in a reference, it may be a typographical variant or a species-specific name.