BALBc
BALB/c, commonly written BALB/c or BALB/c mice, is an inbred laboratory mouse strain that is albino and among the most widely used in biomedical research. The strain is maintained as an inbred line, with common substrains such as BALB/cJ and BALB/cByJ. The white coat results from a recessive mutation in the Tyr gene.
Immunologically, BALB/c mice tend to mount strong humoral responses and exhibit a T helper 2–biased profile,
Applications and limitations: The genetic uniformity of BALB/c mice supports reproducible results, yet substrain differences and
Overall, BALB/c mice remain a foundational model in immunology and cancer biology, valued for their well-characterized