Angiotenzinkonvertáló

Angiotenzinkonvertáló refers to the enzyme angiotensin-converting enzyme, commonly known as ACE. This enzyme plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), a hormonal cascade that regulates blood pressure and fluid balance in the body. ACE catalyzes the conversion of angiotensin I, an inactive peptide, into angiotensin II, a potent vasoconstrictor. Angiotensin II constricts blood vessels, leading to an increase in blood pressure, and also stimulates the release of aldosterone, a hormone that promotes sodium and water retention by the kidneys, further contributing to elevated blood pressure. Dysregulation of the RAAS, often involving increased ACE activity, is implicated in various cardiovascular diseases, including hypertension, heart failure, and kidney disease. Medications that inhibit ACE, known as ACE inhibitors, are widely used to treat these conditions by reducing the production of angiotensin II and consequently lowering blood pressure. ACE also participates in other physiological processes, including the breakdown of bradykinin, a vasodilator. The scientific study and understanding of angiotenzinkonvertáló have been instrumental in developing effective pharmacological interventions for cardiovascular health.