Alphaklotho

Alphaklotho is a type of protein that plays a crucial role in the regulation of cell growth and aging. It is a member of the klotho family of proteins, which are involved in the protection of cells from oxidative stress and in the regulation of mineral ion homeostasis.

Alphaklotho is primarily expressed in the liver and kidney, where it plays a role in the regulation of calcium and phosphate homeostasis. The protein is also involved in the degradation of beta-amyloid peptides, which are associated with the development of Alzheimer's disease. In addition, alphaklotho has been shown to have antioxidant properties, which help to protect cells from damage caused by reactive oxygen species.

Studies have also implicated alphaklotho in the regulation of aging and longevity. Mice that express high levels of alphaklotho have been shown to have enhanced insulin sensitivity and reduced levels of oxidative stress, which are associated with improved healthspan and lifespan.

Alphaklotho has also been linked to the regulation of cardiovascular disease, with studies suggesting that the protein may play a role in the protection against atherosclerosis and other cardiovascular disorders. Further research is needed to fully understand the role of alphaklotho in these diseases, as well as its potential therapeutic applications.

While the exact mechanisms of alphaklotho's effects on aging and disease are still not fully understood, the available evidence suggests that the protein plays a significant role in the regulation of mineral ion homeostasis and the protection against oxidative stress.