Adipogeneesin

Adipogeneesin is a hypothetical signaling molecule proposed to regulate adipogenesis. In speculative biological literature, it is described as a secreted glycoprotein that binds to a yet-unidentified Adipogeneesin Receptor (AGR) to promote the differentiation of mesenchymal stem cells into adipocytes and to enhance lipid accumulation in developing adipose tissue.

Originating as a concept in fictional or theoretical discussions, the term combines adipogenesis with genesis to reflect a proposed initiator role in fat cell formation. It has not been established in peer-reviewed experimental research and is not recognized as an endogenous factor in mainstream biology.

Proposed structure and expression in these accounts describe adipogeneesin as a approximately 25 kDa glycoprotein with a signal peptide for secretion. It is speculated to be expressed by cells in the adipose progenitor niche under hormonal cues or metabolic stress. However, no verified gene sequence, protein structure, or empirical data support its existence in real organisms.

Mechanistically, the hypothetical pathway suggests that binding to AGR activates adipogenic transcription factors such as PPARγ and C/EBPα, upregulating adipogenic genes and promoting lipid droplet formation. It is sometimes depicted as interfacing with MAPK and PI3K signaling and modulating Wnt signaling, though these links remain unsubstantiated in real-world studies.

Status in science and literature is that Adipogeneesin remains a speculative or fictional construct used in discussions of adipogenesis or in science fiction narratives. There is no reproducible experimental evidence confirming its existence or function in humans or model organisms.

See also: Adipogenesis, PPARγ, C/EBP family, adipose tissue development.