ANXA1ANXA11

ANXA1ANXA11 is not a standard, standalone gene or protein symbol in human genomics. In most databases ANXA1 and ANXA11 are listed as separate members of the annexin protein family. The combined string may appear in informal discussions to denote either two distinct proteins, Annexin A1 and Annexin A11, or a hypothetical gene fusion or readthrough event between ANXA1 and ANXA11. There is no widely accepted evidence for a native ANXA1–ANXA11 fusion protein in humans.

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein with roles in membrane trafficking and the resolution of inflammation. It is regulated by glucocorticoids and can be secreted via non-classical pathways. Extracellular Annexin A1 signals through formyl peptide receptors to dampen inflammatory responses, and it participates in processes such as phagocytosis, endocytosis, and membrane organization. Its activity is typically associated with anti-inflammatory and pro-resolving effects in immune and epithelial cells.

Annexin A11 (ANXA11) is a comparatively less characterized member of the family but is implicated in vesicle trafficking and cytoskeletal interactions. It is expressed in a range of tissues and has been studied for potential roles in RNA metabolism and cellular stress responses. Genetic variations in ANXA11 have been linked to neurodegenerative conditions, including familial forms of amyotrophic lateral sclerosis (ALS), suggesting contributions to cellular homeostasis and proteostasis under stress.

Relation and interpretation: Because ANXA1 and ANXA11 perform distinct cellular roles, the term ANXA1ANXA11 typically represents two separate annexins rather than a single functional unit. Any proposal of a combined protein would require rigorous experimental validation and scholarly consensus.