AMLD45

AMLD45, also known as Amiloride-45, is a medication used to treat hyponatremia, a condition characterized by low sodium levels in the blood. It is a potassium-sparing diuretic that works by increasing the levels of sodium ions in the blood, which helps to restore normal sodium concentration.

AMLD45 is a sustained-release formulation of amiloride, a potassium-sparing diuretic that was first introduced in the 1960s. It is available as a 45-milligram tablet, which is taken once a day to avoid increased side effects. Regular use of AMLD45 can help to normalize sodium levels in the blood and prevent hyponatremia.

The mechanism of action of AMLD45 involves its action on the kidneys, where it works to increase sodium reabsorption in the distal convoluted tubule. By increasing sodium reabsorption, AMLD45 helps to reduce the amount of sodium lost in the urine. This, in turn, helps to increase sodium levels in the blood and restore normal hydration status.

Side effects of AMLD45 may include hyperkalemia (elevated potassium levels in the blood), dizziness, headache, and nausea. Regular blood work is recommended to monitor for hyperkalemia, which can be a potentially serious condition.

AMLD45 is contraindicated in individuals with severe kidney impairment, acute kidney injury, and those who are allergic to amiloride or other potassium-sparing diuretics. Patients should be closely monitored for side effects, especially if they have pre-existing conditions such as kidney disease or heart failure.