AAVviruksia
AAVviruksia, commonly known as adeno-associated viruses, are small viruses that belong to the parvovirus family. They are not known to cause disease in humans, making them attractive candidates for gene therapy applications. AAVs are single-stranded DNA viruses that require a helper virus, such as adenovirus, to replicate efficiently. However, they can infect cells without a helper virus, entering a latent state where their genome integrates into the host cell's DNA, typically at a specific locus on chromosome 19.
The genome of AAV is about 4.7 kilobases long and encodes for proteins involved in replication, assembly,
Research into AAVs began in the 1960s, and their potential as gene delivery vehicles was recognized early