35Dimethoxy

3,5-Dimethoxy, often written as 3,5-dimethoxy, is a chemical descriptor used in organic chemistry to indicate two methoxy groups (–OCH3) attached to an aromatic ring at the 3 and 5 positions. It is not a single compound but a substitution pattern found in a wide range of molecules.

The methoxy groups are electron-donating by resonance, which increases the electron density of the aromatic ring. This can influence the ring’s reactivity in electrophilic substitutions and affect properties such as lipophilicity, polarity, and metabolic stability. The 3,5-dimethoxy arrangement can also alter the orientation and outcome of subsequent chemical transformations in synthetic routes.

The motif appears in various synthetic and natural products, serving as a functional handle in medicinal chemistry and materials science. It is used to tune electronic and steric characteristics of aromatic scaffolds, enabling exploration of structure–activity relationships and receptor interactions in research contexts. In some cases, compounds bearing a 3,5-dimethoxy pattern have been studied for psychoactive or pharmacological effects; where relevant, such substances are subject to legal controls and safety considerations.

See also: methoxy group; dimethoxy substitution; aromatic substitution patterns. Regulation and safety notes: substituted phenyl compounds can be regulated in many jurisdictions, and proper compliance with applicable laws and safety guidelines is required in both research and handling.