2Hydroxybenzoyl

2-Hydroxybenzoyl is an organic compound with the chemical formula C7H5O3. It is a derivative of benzoic acid, where the hydroxyl group (-OH) is attached to the benzene ring at the 2nd carbon position. This compound is a key intermediate in the synthesis of various pharmaceuticals and other organic chemicals.

The compound can be produced through the oxidation of 2-aminobenzoyl or the hydrolysis of 2-benzoyl chloride. It is a white to off-white crystalline solid, soluble in water and most organic solvents. 2-Hydroxybenzoyl is used in the production of drugs such as ibuprofen and naproxen, which are nonsteroidal anti-inflammatory drugs (NSAIDs). It is also a precursor in the synthesis of other pharmaceutical compounds, including some antibiotics and antiviral agents.

2-Hydroxybenzoyl is a reactive intermediate due to the presence of the hydroxyl group, which can undergo various reactions such as esterification, amidation, and condensation. These reactions are often used to introduce different functional groups into the molecule, leading to the formation of more complex organic compounds.

Safety precautions must be taken when handling 2-hydroxybenzoyl due to its reactivity and potential irritant properties. It should be stored in a cool, dry place away from incompatible substances and sources of ignition. Personal protective equipment, such as gloves and safety glasses, should be worn when working with this compound.

In summary, 2-hydroxybenzoyl is a significant intermediate in organic synthesis with applications in pharmaceutical chemistry. Its reactivity and potential hazards make it an important compound to understand and handle with care.