2Deoxy2methylglucose

2-Deoxy-2-methylglucose, also known as 2-deoxy-2-methyl-D-glucose or 2-D-methyl glucose, is a synthetic derivative of glucose. It is a structural analog of glucose that has been modified with a methyl group at the 2-position of the glucose ring. This modification results in a molecule that is pharmacologically inactive but provides valuable research and diagnostic applications.

The structural similarity between 2-deoxy-2-methylglucose and glucose allows it to bind to glucose receptors, including the glucose transporter Glut. However, the methyl group renders it unable to undergo phosphorylation, making it a useful tool for studying glucose metabolism and drug development. 2-Deoxy-2-methylglucose has been used to investigate aspects of glucose transport and metabolism, including glucose homeostasis, insulin resistance, and cancer metabolism.

The compound has been used in research settings to investigate glucose uptake and metabolism in cells. It has been used in conjunction with radioactive isotopes or fluorescent dyes to track glucose activity, providing valuable insights into physiological and pathological processes. 2-Deoxy-2-methylglucose has also been explored as a potential anti-cancer agent due to its ability to selectively inhibit glucose uptake in cancer cells.

While it shows promise in various medical applications, it is essential to note that 2-deoxy-2-methylglucose is not suitable for human consumption and is generally restricted to in vitro and in vivo research settings. Its potential as a diagnostic and therapeutic tool is being explored through ongoing research.