2CK

2C-K, also written 2C-K, is a synthetic psychedelic compound in the 2C family of phenethylamines. It was developed in the late 20th century and has appeared on the designer-drug market as a research chemical. Like other 2C compounds, it is typically encountered as a white powder or tablet. The chemical name is 2,5-dimethoxy-4-ethylphenethylamine.

Chemistry: It features methoxy groups at positions 2 and 5 and an ethyl substituent at position 4 on the phenyl ring.

Pharmacology and effects: 2C-K is a serotonergic psychedelic that acts as an agonist at 5-HT2A receptors, with activity at related serotonin receptors. Reported effects include visual enhancements, color intensification, altered perception of time, and changes in mood or thought. Onset typically 30–90 minutes after ingestion with a duration of roughly 6–12 hours, though this varies with dose and individual factors. Adverse effects can include anxiety, paranoia, agitation, increased heart rate or blood pressure, nausea, and, in some cases, dangerous cardiovascular or thermoregulatory responses.

Safety and legality: Because there is limited clinical data and batch-to-batch potency can vary, use carries substantial risk. There have been reports of severe anxiety, paranoia, and cardiovascular stress. It is illegal or controlled in many jurisdictions, with legal status differing by country.

See also: Other compounds in the 2C series such as 2C-B, 2C-I, and 2C-E.