1245tetrazine
1,2,4,5-tetrazine is a six-membered heteroaromatic ring that contains four nitrogen atoms at positions 1, 2, 4 and 5 and two carbon atoms at positions 3 and 6. The ring is highly electron-deficient and planar, making it a versatile scaffold for chemical modification. Substituted derivatives of the 1,2,4,5-tetrazine core are commonly prepared, with the 3 and 6 positions often bearing functional groups to tune reactivity and solubility.
A defining feature of 1,2,4,5-tetrazines is their reactivity in inverse electron-demand Diels–Alder (IEDDA) reactions. They react
Applications of the tetrazine motif include bioorthogonal labeling, imaging, and pretargeting strategies in biomedical research. Tetrazine