10q233

10q233 is not a standard cytogenetic designation in human genomics. The notation most closely resembles 10q23.3, a well-characterized region on the long arm of chromosome 10. Cytogenetic bands use decimals to indicate subbands, and 10q23.3 is the conventional reference rather than 10q233.

The region 10q23.3 is notable for containing the PTEN gene, a major tumor suppressor. PTEN encodes a lipid and protein phosphatase that antagonizes the PI3K/AKT signaling pathway, helping regulate cell growth, survival, and metabolism. Pathogenic alterations of PTEN, including deletions, mutations, or promoter changes, can disrupt its function and are associated with cancer predisposition and PTEN hamartoma tumor syndrome, which encompasses conditions such as Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome. In cancers, loss or inactivation of PTEN can contribute to increased cellular proliferation and tumor progression.

Beyond PTEN, the exact gene content of any given interval in 10q23.3 can vary with genome assembly and annotation. Cytogenetic analyses in this region often focus on detecting copy-number changes, loss of heterozygosity, or sequence variants that may influence disease risk or progression. For researchers and clinicians, coordinates are typically reported using current genome builds (for example GRCh38/hg38) and accessed through genome browsers such as UCSC or Ensembl.

If the intended locus differs from 10q23.3, providing the precise coordinate or subband would help tailor the article to that specific region.