yage

Yage, also known as ayahuasca, is a psychoactive brew traditionally prepared by indigenous peoples of the Amazon basin. The primary ingredients are typically the leaves of the Psychotria viridis shrub and the vine of the Banisteriopsis caapi plant. These plants contain psychoactive compounds, primarily N,N-dimethyltryptamine (DMT) in Psychotria viridis and monoamine oxidase inhibitors (MAOIs) in Banisteriopsis caapi. The combination of DMT and MAOIs is crucial for the brew's oral psychoactivity, as DMT is rapidly broken down by enzymes in the digestive system unless inhibited by MAOIs.

The consumption of yage is often accompanied by ritualistic practices and is used for spiritual, medicinal, and divinatory purposes. Users typically experience profound altered states of consciousness, including vivid hallucinations, introspection, and emotional release. The effects can vary significantly depending on the specific preparation, the individual, and the setting.

In recent decades, yage has gained attention outside of its traditional cultural context, leading to its use in various therapeutic and spiritual settings worldwide. However, its legal status varies by country, and concerns exist regarding its potential psychological effects, the importance of set and setting, and the need for experienced guidance during its use. Research into the potential therapeutic applications of yage, particularly for mental health conditions, is ongoing.