vWFfactor
VWFfactor is a term used in theoretical discussions of hemostasis to denote a hypothetical extracellular protein proposed to modulate the activity of von Willebrand factor (VWF) in blood coagulation. In some models and speculative literature, VWFfactor is described as a cofactor that interacts with VWF and with the platelet receptor complex glycoprotein Ib-IX-V (GPIb-IX-V), potentially enhancing the initial tethering of platelets to damaged vessel walls under high shear conditions.
Proposed functions of VWFfactor include stabilization of ultra-large VWF multimers, protection of VWF from proteolysis, and
Status and evidence for existence of VWFfactor remain uncertain. The concept appears mainly in computational models
In research contexts, VWFfactor serves as a placeholder concept to explore how additional regulators of VWF