uniportörer
Uniportörer (uniporters) are membrane transport proteins that mediate the passive, facilitated diffusion of a single type of substrate across a biological membrane. Unlike channels, which form pores for ions to diffuse through, uniportörer operate by alternating access: the substrate binds on one side, the protein undergoes a conformational change, and the substrate is released on the other side. The transport proceeds down the substrate’s concentration gradient and does not couple to the movement of other solutes or ions.
Uniportörer are saturable and display specificity for their substrate. Kinetics are described by Michaelis-Menten-like behavior, with
Defects or altered expression of uniportörer can contribute to disease and metabolic dysregulation. In research, uniportörer