ubikuitiniintijärjestelmän
Ubikuitiniintijärjestelmän, often referred to as the ubiquitin-proteasome system (UPS), is a fundamental cellular process in eukaryotic organisms responsible for protein degradation. This intricate pathway plays a critical role in maintaining cellular homeostasis by removing damaged, misfolded, or no longer needed proteins. The system comprises two main components: ubiquitin, a small regulatory protein, and the proteasome, a large protein complex that acts as a cellular garbage disposal.
The process begins with the selective tagging of target proteins for degradation by the covalent attachment
The 26S proteasome, a barrel-shaped structure, unfolds the ubiquitinated protein and threads it into its core,