topoDNA
TopoDNA is a computational tool designed to analyze and visualize the three-dimensional structure of DNA molecules, particularly focusing on topological properties. Developed by researchers in computational biology, it combines algorithms from graph theory, geometry, and physics to simulate and study the spatial organization of DNA, including its supercoiling, knotting, and linking behavior. The software is particularly useful for investigating how DNA topology influences biological processes such as replication, transcription, and chromosome organization.
The tool allows users to model DNA as a continuous filament or as a series of linked
TopoDNA has applications in structural biology, bioinformatics, and synthetic biology. It aids in understanding how topological
The software is open-source and available for download, with documentation and tutorials provided to assist users